Giuseppe Remuzzi Selected Research

Shiga Toxin (Shigella Toxin)

1/2022	Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome.
1/2019	Complement Activation Contributes to the Pathophysiology of Shiga Toxin-Associated Hemolytic Uremic Syndrome.
8/2014	Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement.
3/2014	Cardiovascular complications in atypical haemolytic uraemic syndrome.
10/2012	Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice.
7/2011	Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis.
7/2009	Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
12/2006	Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling.
8/2006	Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.
1/2006	Outcome of renal transplantation in patients with non-Shiga toxin-associated hemolytic uremic syndrome: prognostic significance of genetic background.

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Giuseppe Remuzzi Research Topics

Disease

115	Proteinuria 01/2022 - 01/2000
72	Chronic Kidney Failure (Chronic Renal Failure) 01/2019 - 01/2000
60	Type 2 Diabetes Mellitus (MODY) 03/2022 - 07/2002
60	Chronic Renal Insufficiency 12/2021 - 01/2002
46	Albuminuria 03/2022 - 09/2002
41	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022 - 09/2002
36	Inflammation (Inflammations) 11/2020 - 04/2002
35	Hypertension (High Blood Pressure) 01/2021 - 07/2002
34	Kidney Diseases (Kidney Disease) 01/2022 - 09/2002
31	Atypical Hemolytic Uremic Syndrome 01/2022 - 01/2006
31	Disease Progression 01/2021 - 05/2002
29	Membranous Glomerulonephritis (Membranous Nephropathy) 11/2020 - 05/2001
23	Hemolytic-Uremic Syndrome 01/2022 - 02/2001
23	Nephrotic Syndrome (Syndrome, Nephrotic) 11/2020 - 09/2002
22	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 11/2004
20	Infections 01/2022 - 04/2000
19	Renal Insufficiency (Renal Failure) 01/2022 - 12/2001
19	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2022 - 07/2005
18	Thrombosis (Thrombus) 01/2022 - 01/2002
17	Thrombotic Thrombocytopenic Purpura 11/2020 - 01/2002
16	Heart Failure 01/2022 - 12/2002
15	Hemolytic Anemia 01/2022 - 03/2006
14	Thrombocytopenia (Thrombopenia) 01/2022 - 08/2005
14	Fibrosis (Cirrhosis) 01/2020 - 05/2006
13	Anemia 01/2021 - 03/2005
12	COVID-19 01/2022 - 01/2020
12	Neoplasms (Cancer) 01/2021 - 04/2000
10	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 10/2003
10	Glomerulonephritis 01/2021 - 06/2006
9	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 01/2021 - 03/2012
9	Insulin Resistance 05/2018 - 09/2004
9	Diabetes Complications 10/2013 - 11/2004
9	Delayed Graft Function 01/2012 - 03/2002
8	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 07/2010
8	Thrombotic Microangiopathies 11/2020 - 01/2002
8	Stroke (Strokes) 01/2019 - 07/2004
8	Cysts 01/2019 - 07/2005
7	Body Weight (Weight, Body) 03/2022 - 07/2003
7	IGA Glomerulonephritis (IGA Nephropathy) 01/2022 - 07/2003
7	Lupus Nephritis 01/2017 - 05/2007
7	Ischemia 11/2013 - 03/2002
6	Dyslipidemias (Dyslipidemia) 01/2019 - 02/2003
6	Cicatrix (Scar) 11/2014 - 12/2002
5	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 12/2021 - 05/2008
5	Reperfusion Injury 01/2020 - 03/2002

Drug/Important Bio-Agent (IBA)

63	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2000
58	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2019 - 03/2000
55	Complement System Proteins (Complement)IBA 01/2022 - 11/2003
45	CreatinineIBA 03/2022 - 02/2002
24	Angiotensin IIIBA 01/2020 - 05/2001
24	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 10/2019 - 12/2001
23	Angiotensin Receptor AntagonistsIBA 01/2019 - 12/2002
22	Complement Factor H (Factor H)IBA 10/2019 - 02/2001
20	AlbuminsIBA 01/2019 - 03/2000
19	Pharmaceutical PreparationsIBA 12/2021 - 09/2002
18	Rituximab (Mabthera)FDA Link 01/2021 - 09/2002
18	thiamine triphosphorate (TTP)IBA 11/2020 - 02/2001
16	Ramipril (Altace)FDA LinkGeneric 01/2021 - 01/2000
15	Hemoglobins (Hemoglobin)IBA 01/2019 - 06/2004
15	Antihypertensive Agents (Antihypertensives)IBA 05/2018 - 01/2002
14	SteroidsIBA 12/2021 - 07/2003
14	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2009
14	Lisinopril (Prinivil)FDA LinkGeneric 01/2020 - 03/2000
13	AntibodiesIBA 01/2021 - 07/2003
13	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 05/2002
13	Losartan (Cozaar)FDA LinkGeneric 01/2018 - 09/2001
11	Shiga Toxin (Shigella Toxin)IBA 01/2022 - 01/2003
11	Darbepoetin alfa (Aranesp)FDA Link 01/2019 - 03/2005
10	eculizumab FDA Link 01/2022 - 03/2012
10	nephrinIBA 01/2022 - 05/2001
10	CholesterolIBA 05/2018 - 05/2002
9	trandolapril (Mavik)FDA LinkGeneric 01/2019 - 11/2004
9	LipidsIBA 01/2019 - 07/2007
8	Serum AlbuminIBA 01/2020 - 09/2002
8	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2015 - 01/2000
7	AutoantibodiesIBA 01/2020 - 08/2005
7	Octreotide (Sandostatin)FDA LinkGeneric 01/2019 - 07/2005
6	Blood Glucose (Blood Sugar)IBA 03/2022 - 05/2011
6	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2022 - 09/2014
6	Antigen-Antibody Complex (Immune Complex)IBA 01/2021 - 11/2013
6	Valsartan (Vals)FDA Link 01/2021 - 03/2003
6	Monoclonal AntibodiesIBA 01/2021 - 09/2002
6	EnzymesIBA 11/2020 - 08/2005
6	Sirtuin 3IBA 01/2020 - 01/2010
6	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2019 - 07/2005
6	SodiumIBA 01/2018 - 01/2000
6	Cisplatin (Platino)FDA LinkGeneric 10/2017 - 11/2007
6	AtrasentanIBA 09/2017 - 05/2014
5	SaltsIBA 01/2022 - 04/2007
5	LDL CholesterolIBA 01/2021 - 02/2003
5	HematinicsIBA 01/2021 - 07/2009
5	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2020 - 01/2005
5	Iohexol (Omnipaque)FDA Link 01/2020 - 01/2012
5	AntigensIBA 01/2020 - 02/2006

Therapy/Procedure

123	Therapeutics 01/2022 - 01/2002
31	Kidney Transplantation 01/2021 - 01/2002
20	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2021 - 11/2004
15	Transplantation 01/2021 - 11/2004
11	Renal Dialysis (Hemodialysis) 01/2021 - 01/2002
11	Organ Transplantation 01/2019 - 04/2000